Renal fibroblasts and myofibroblasts in chronic kidney disease.

  title={Renal fibroblasts and myofibroblasts in chronic kidney disease.},
  author={Frank M Strutz and Michael Zeisberg},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={17 11},
F ibroblasts and myofibroblasts are believed to be the key effector cells in renal fibrogenesis responsible for the synthesis and deposition of extracellular matrix components. In an editorial written 15 yr ago, Gown claimed to have the mysteries of the fibroblast (partially) unmasked (1). Unfortunately, 15 yr later many mysteries of the fibroblast and myofibroblasts remain intact and we are only beginning to solve the riddle this cell poses. This manuscript summarizes current understanding of… CONTINUE READING