Renal failure increases gastric mucosal blood flow and acid secretion in rats: role of endothelium-derived nitric oxide.

@article{Quintero1992RenalFI,
  title={Renal failure increases gastric mucosal blood flow and acid secretion in rats: role of endothelium-derived nitric oxide.},
  author={Enrique Quintero and Paul H. Guth},
  journal={The American journal of physiology},
  year={1992},
  volume={263 1 Pt 1},
  pages={G75-80}
}
Because of the contradictory findings in clinical studies, and the complete lack of animal studies, the purpose of this investigation was to characterize the changes in gastric mucosal blood flow (GMBF) and acid secretion in an animal model of chronic renal failure. Rats with chronic renal failure induced by partial kidney infarction had a significantly higher basal GMBF and lower gastric vascular resistance than control rats. The gastric acid secretory and mucosal hyperemic response to… CONTINUE READING

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