Renal failure and multiple myeloma: pathogenesis and treatment of renal failure and management of underlying myeloma.

@article{Clark1999RenalFA,
  title={Renal failure and multiple myeloma: pathogenesis and treatment of renal failure and management of underlying myeloma.},
  author={Alan L. Clark and Anupkumar Shetty and Richard Soutar},
  journal={Blood reviews},
  year={1999},
  volume={13 2},
  pages={79-90}
}
Renal impairment is a common complication of multiple myeloma occuring in 50% of patients at some stage in their disease. Pathogenesis is multifactorial. Nephrotoxic manifestations of monoclonal immunoglobulin overexpression include the 'myeloma kidney', light chain deposition disease, AL amyloid, plasma cell infiltration and glomerulonephritis. Other factors, such as hypercalcaemia, hyperuricaemia, infection, hyperviscocity and nephrotoxic drugs can precipitate or exacerbate acute and chronic… CONTINUE READING

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