Renal expression of metallothionein in rats treated with cadmium

@article{Kuwahara2002RenalEO,
  title={Renal expression of metallothionein in rats treated with cadmium},
  author={Michio Kuwahara and Takayuki Ota and Yu Gu and Tomoki Asai and Yoshio Terada and Takashi Akiba and Fumiaki Marumo},
  journal={Clinical and Experimental Nephrology},
  year={2002},
  volume={6},
  pages={79-84}
}
Background. The intrarenal localization of metallothionein (MT) expression has not been studied in detail. Therefore, we investigated the effects of acute exposure to cadmium on the renal expression of MT. Methods. MT mRNA expression was estimated quantitatively at 2, 6, 24, and 72 h after the injection of cadmium (1 mg/kg) to the intraperitoneum of male Sprague-Dawley rats. The site of cadmium-induced MT mRNA expression was determined, by the reverse transcription polymerase chain reaction… CONTINUE READING

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