Renal excretion of perfluorooctanoic acid in male rats: inhibitory effect of testosterone.

@article{Heuvel1992RenalEO,
  title={Renal excretion of perfluorooctanoic acid in male rats: inhibitory effect of testosterone.},
  author={John P. Vanden Heuvel and James W. Davis and Ronald K. Sommers and Richard Einer Peterson},
  journal={Journal of biochemical toxicology},
  year={1992},
  volume={7 1},
  pages={
          31-6
        }
}
There is a marked sex difference in the whole-body elimination of perfluorooctanoic acid (PFOA) in rats, with females excreting the perfluorinated acid much more rapidly (half life [t1/2] less than 1 day) than males (t1/2 = 15 days). Our objective was to determine if androgens or estrogens are involved in causing this sex difference in PFOA elimination. Castration of males greatly increased the elimination of [1-14C]PFOA (9.4 mumol/kg, i.p.) in urine, demonstrating that a factor produced by the… CONTINUE READING

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