Renal endothelial injury and microvascular dysfunction in acute kidney injury.

@article{Verma2015RenalEI,
  title={Renal endothelial injury and microvascular dysfunction in acute kidney injury.},
  author={Sudhanshu Kumar Verma and Bruce A Molitoris},
  journal={Seminars in nephrology},
  year={2015},
  volume={35 1},
  pages={96-107}
}
The kidney is comprised of heterogeneous cell populations that function together to perform a number of tightly controlled, complex and interdependent processes. Renal endothelial cells contribute to vascular tone, regulation of blood flow to local tissue beds, modulation of coagulation and inflammation, and vascular permeability. Both ischemia and sepsis have profound effects on the renal endothelium, resulting in microvascular dysregulation resulting in continued ischemia and further injury… CONTINUE READING

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