Renal endothelial dysfunction in acute kidney ischemia reperfusion injury.

@article{Basile2014RenalED,
  title={Renal endothelial dysfunction in acute kidney ischemia reperfusion injury.},
  author={D P Basile and Mervin C. Yoder},
  journal={Cardiovascular & hematological disorders drug targets},
  year={2014},
  volume={14 1},
  pages={
          3-14
        }
}
Acute kidney injury is associated with alterations in vascular tone that contribute to an overall reduction in GFR. Studies in animal models indicate that ischemia triggers alterations in endothelial function that contribute significantly to the overall degree and severity of a kidney injury. Putative mediators of vasoconstriction that may contribute to the initial loss of renal blood flow and GFR are highlighted. In addition, there is discussion of how intrinsic damage to the endothelium… CONTINUE READING

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