Renal effects of the calcium channel blocker aranidipine and its active metabolite in anesthetized dogs and conscious spontaneously hypertensive rats.

@article{Ichihara1998RenalEO,
  title={Renal effects of the calcium channel blocker aranidipine and its active metabolite in anesthetized dogs and conscious spontaneously hypertensive rats.},
  author={Kenji Ichihara and Keiichi Okumura and Hiroyuki Kamei and Mitsuaki Nagasaka and Atsuhiro Kanda and Tomohiro Kanno and Kazuhisa Miyoshi and Hidekazu Miyake},
  journal={Journal of cardiovascular pharmacology},
  year={1998},
  volume={31 2},
  pages={
          277-85
        }
}
The purpose of this study was to investigate the renal effects of aranidipine, a novel calcium channel blocker of the dihydropyridine type, and its active metabolite in anesthetized dogs and conscious spontaneously hypertensive rats (SHRs). When infused into the renal artery in anesthetized dogs, aranidipine (0.03 microg/kg/min) induced sustained increases in urine volume and urinary excretion of sodium and of potassium. This effect was greater than that elicited by nifedipine (0.1 microg/kg… 
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