Renal effects of the calcium channel blocker aranidipine and its active metabolite in anesthetized dogs and conscious spontaneously hypertensive rats.

  title={Renal effects of the calcium channel blocker aranidipine and its active metabolite in anesthetized dogs and conscious spontaneously hypertensive rats.},
  author={Kenji Ichihara and Keiichi Okumura and Hiroyuki Kamei and Mitsuaki Nagasaka and Atsuhiro Kanda and Tomohiro Kanno and Kazuhisa Miyoshi and Hidekazu Miyake},
  journal={Journal of cardiovascular pharmacology},
  volume={31 2},
The purpose of this study was to investigate the renal effects of aranidipine, a novel calcium channel blocker of the dihydropyridine type, and its active metabolite in anesthetized dogs and conscious spontaneously hypertensive rats (SHRs). When infused into the renal artery in anesthetized dogs, aranidipine (0.03 microg/kg/min) induced sustained increases in urine volume and urinary excretion of sodium and of potassium. This effect was greater than that elicited by nifedipine (0.1 microg/kg… 
Distinct action of aranidipine and its active metabolite on renal arterioles, with special reference to renal protection.
Aranidipine has dilator action on both arterioles, whereas M-1 caused predominant dilation of afferent arteriole, which may constitute a determinant of efferent arteriolar action of the calcium antagonist.
Reduction of cerebral injury in stroke-prone spontaneously hypertensive rats by amlodipine.
Dihydropyridine Ca(2+) channel antagonists, initiated together with high salt intake, prevent the development of hypertension and subsequent cerebral damage in stroke-prone spontaneously hypertensive
Efficacy and Safety of Aranidipine Enteric-coated Tablets Compared With Amlodipine in Chinese Patients With Mild to Moderate Essential Hypertension: A Multicenter, Randomized, Double-blind, Parallel-Controlled Clinical Trial
It is concluded that once-daily administration of aranidipine (5–10 mg) effectively controlled blood pressure, and the short-term treatment might result in it being less effective than amlodipine.
Pharmacokinetic and pharmacodynamic characteristics of aranidipine sustained-release, enteric-coated tablets in healthy Chinese men: a phase I, randomized, open-label, single- and multiple-dose study.
The aim of this study was to explore the pharmacokinetic and pharmacodynamic properties and safety profiles of aranidipine and its active M-1 metabolite in healthy Chinese men and found no significant differences in any PK parameter between dose groups.
Pharmacological modulators of voltage-gated calcium channels and their therapeutical application.
Calcium channels play an important role in the transduction of action potential to the cytosol, an influx of Ca(2+) is essential for muscle contraction, neurotransmitter, and hormonal release, and blockers of neuronal CCs may be applied for pain treatment.
Therapeutical application of voltage-gated calcium channel modulators
Calcium channels play an important role in the transduction of the signal from the cell periphery to the cytosol. Entering Ca2+ acts as a the second messenger, triggering muscle contraction,


Effects of benidipine on renal function in anesthetized spontaneously hypertensive rats.
Results suggest that benidipine produces diuresis and natriuresis by the inhibition of water and Na reabsorption at both the proximal tubule and the distal nephron in anesthetized spontaneously hypertensive rats.
Effects of the Calcium Antagonist Nicardipine on Renal Function and Renin Release in Dogs
The data suggest that nicardipine did not inhibit sodium transport at the medullary portion of the ascending limb of Henle, and that the increase in GFR might induce an enhancement of the delivery of sodium to the Henle loop.
Cardiovascular and Renal Actions of Calcium Channel Blocker Chemical Subgroups: a Search for Renal Specificity
Diuretic responses evoked by the Ca2+ channel blockers were not class‐specific, showed no tendency towards sparing K+, were generally weaker than those produced by low doses of amiloride or hydrochlorothiazide, and were dissociable from drug‐induced changes in blood pressure.
The effect of indomethacin on renal function in pentobarbital-anesthetized dogs.
The data suggest that in the anesthetized dog, endogenous prostaglandins may serve to maintain renal blood flow but not glomerular filtration rate, and the early decrease in urine flow rate correlated closely with the decrease in sodium excretion.
Effects of intrarenal infusion of calcium entry blockers in anesthetized dogs.
A striking effect of calcium entry blockers on the reabsorption of sodium, chloride, and water by the renal tubules in intact dogs but renin release did not increase unless hypotension occurred, as demonstrated in anesthetized, uninephrectomized dogs.
Renal effects of felodipine: a review of experimental evidence and clinical data.
  • G. Dibona
  • Medicine
    Journal of cardiovascular pharmacology
  • 1990
The dihydropyridine calcium channel antagonist felodipine produces renal vasodilatation (normal or increased but not decreased RBF) without adverse effects on the GFR or renal sodium and water retention.
A study of the renal actions of amlodipine in the normotensive and spontaneously hypertensive rat
  • E. Johns
  • Chemistry, Medicine
    British journal of pharmacology
  • 1988
These doses of amlodipine caused modest reductions in blood pressure, minimal changes in renal haemodynamics and a natriuresis and diureis and it is suggested that the changes in tubular fluid handling were compatible with depression of reabsorption further along the tubule.
Renal hemodynamic and tubular transport effects of nitrendipine.
Results indicate that nitrendipine has direct tubular effects on renal electrolyte transport and that the locus of these effects is probably the proximal tubule, rather than sodium retentive, as previously reported.
Regional vascular effects of MPC-1304, a novel dihydropyridine derivative, in conscious normotensive and spontaneously hypertensive rats.
It is suggested that MPC-1304 possesses a genetic hypertension-dependent renal vasodilating action, unlike nifedipine and manidipine, in conscious spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY).
Antihypertensive Effects of MPC-1304, a Novel Calcium Antagonist, in Experimental Hypertensive Rats and Dogs
In conclusion, MPC-1304 and its active metabolites have potent antihypertensive effects and cause slight tachycardia, and they may be useful in treating hypertension.