Renal effects of selective cyclooxygenase‐2 inhibition in normotensive salt‐depleted subjects

@article{Rossat1999RenalEO,
  title={Renal effects of selective cyclooxygenase‐2 inhibition in normotensive salt‐depleted subjects},
  author={Julien Rossat and Marc P Maillard and J{\"u}rg Nussberger and H. R. Brunner and Michel Burnier},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1999},
  volume={66}
}

Renal effects of cyclo‐oxygenase‐2 inhibition

TLDR
The renal cyclo‐oxygenase (COX)‐2 isoenzyme has an important role in the maintenance of renal homeostasis, particularly in the setting of reduced renal perfusion, and the clinical risk of renal impairment, salt and water retention, and electrolyte disturbance should be considered.

Celecoxib does not alter cardiovascular and renal function during dietary salt loading

TLDR
The hypothesis that a clinical dose of celecoxib would impair urinary sodium excretion and elevate blood pressure (BP) during dietary salt loading is tested.

Comparison of rofecoxib, celecoxib, and naproxen on renal function in elderly subjects receiving a normal‐salt diet

TLDR
This study compared directly the renal effects of two selective cyclooxygenase (COX)‐2 inhibitors with naproxen (dual COX‐1/COX‐2 inhibitor) and placebo in healthy elderly subjects on a sodium‐replete diet.

COX-2 Inhibitors and the Kidney

TLDR
COX-2 inhibitors may have much the same renal risks that a standard NSAID does, and clinical trials have already focused on the new drugs' renal effects.

Renal effects of cyclooxygenase-2 selective inhibitors

TLDR
Clinical data verify that selective inhibitors of cyclooxygenase-2 affect renal function to a degree similar to that which has previously been documented with nonselective nonsteroidal anti-inflammatory drugs.

Alterations in renal cytosolic phospholipase A2 and cyclooxygenases in polycystic kidney disease

TLDR
Cytosolic phospholipase A2, cPLA2, cyclooxygenase‐1, and COX‐1 regulate the formation of physiologically active prostaglandins, the production of which is known to be elevated in several renal disorders.

fl RENAL EFFECTS OF SELECTIVE CYCLOOXYGENASE-2 INHIBITORS IN RAT : A LIGHT AND ELECTRON MICROSCOPIC STUDY

TLDR
A major drawback with nonselective NSAIDs has been the gastrointestinal (GI) erosions, bleeding, salt retention and occasionally acute renal failure.

Effects of Selective vs. Nonselective Cyclooxygenase Inhibition on Dynamic Renal Potassium Excretion: A Randomized Trial

TLDR
A mixed‐effects model statistical approach is applied that allows investigation of drug‐induced delays in reaching maximal potassium excretion, blunting/flattening of potassium handling curves, and shift/separation in potassium handling at peakassium excretion.

COX-2 inhibitors and renal function in elderly people.

  • B. Chen
  • Medicine
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
  • 2000
TLDR
Effect of cyclooxygenase-2 inhibition on renal function in elderly persons receiving a low-salt diet in elderly people receiving a high-sALT diet is studied.
...

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TLDR
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TLDR
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TLDR
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TLDR
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