Renal effects of in utero exposure to mercuric chloride in rats

@article{Bernard1992RenalEO,
  title={Renal effects of in utero exposure to mercuric chloride in rats},
  author={Alfred Bernard and Catherine Collette and Robert Lauwerys},
  journal={Archives of Toxicology},
  year={1992},
  volume={66},
  pages={508-513}
}
The transplacental nephrotoxicity of mercuric chloride has been studied in female Sprague-Dawley rats. Mercuric chloride was injected s. c. to rats at the dose of 1 mg/kg during the last 8 gestational days or the whole pregnancy. Both mothers and newborns developed a transient renal dysfunction resulting in an increased urinary excretion of beta2-microglobulin and albumin. In mothers and their female offspring, these effects were completely reversible and did not influence the subsequent… CONTINUE READING