Renal drug transporters and nephrotoxicity

  title={Renal drug transporters and nephrotoxicity},
  author={Naohiko Anzai and Hitoshi Endou},
Among drug-induced renal failure, direct renal tubular toxicity, typically described as toxic acute tubular necrosis, is often associated with increased cellular uptake of nephrotoxic compounds. Drug transporters in tubular cells are the first fundamental stage in the development of the nephrotoxic process. Several examples can be given of organic substances that are nephrotoxic only after being transported into the cells. Recent advances in molecular cloning have identified several families of… CONTINUE READING
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Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules

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