Renal denervation restores the baroreflex control of renal sympathetic nerve activity and heart rate in Wistar-Kyoto rats with cisplatin-induced renal failure.

@article{Khan2014RenalDR,
  title={Renal denervation restores the baroreflex control of renal sympathetic nerve activity and heart rate in Wistar-Kyoto rats with cisplatin-induced renal failure.},
  author={Shahbaz Ahmad Khan and M. A. Sattar and Hassaan Anwer Rathore and Mohammed H. Abdulla and F Ud Din Ahmad and Arfan Ahmad and Samina Afzal and Nor Azizan Abdullah and Edward James Johns},
  journal={Acta physiologica},
  year={2014},
  volume={210 3},
  pages={
          690-700
        }
}
AIM There is evidence that in chronic renal failure, the sympathetic nervous system is activated. This study investigated the role of the renal innervation in suppressing high- and low-pressure baroreflex control of renal sympathetic nerve activity and heart rate in cisplatin-induced renal failure. METHODS Renal failure was induced using cisplatin (5 mg kg(-1) , i.p.) and the rats used 7 days later. Groups of rats were anaesthetized and prepared for measurement of renal sympathetic nerve… CONTINUE READING
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