Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease.

@article{Eriguchi2015RenalDH,
  title={Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease.},
  author={Masahiro Eriguchi and Kazuhiko Tsuruya and Naoki Haruyama and Shunsuke Yamada and Shigeru Tanaka and Takaichi Suehiro and Hideko Noguchi and Kosuke Masutani and Kumiko Torisu and Takanari Kitazono},
  journal={Kidney international},
  year={2015},
  volume={87 1},
  pages={116-27}
}
We elucidate the underlying mechanisms of bidirectional cardiorenal interaction, focusing on the sympathetic nerve driving disruption of the local renin-angiotensin system (RAS). A rat model of N(ω)-nitro-L-arginine methyl ester (L-NAME; a nitric oxide synthase inhibitor) administration was used to induce damage in the heart and kidney, similar to cardiorenal syndrome. L-NAME induced sympathetic nerve-RAS overactivity and cardiorenal injury accompanied by local RAS elevations. These were… CONTINUE READING
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