Renal concentrating ability in mice: A model for the use of genetic variation in elucidating relationships between structure and function

In Os/+ mice of the XVIII strain, nephron number was reduced by 80% and GFR by 50%. Plots of (U/P)Osm against percentage filtered solute load excreted showed that the consequent osmotic diuresis per nephron was a sufficient explanation for the mild concentrating defect in XVIII Os/+ mice. This conclusion was confirmed by the fact that subtotal nephrectomy… (More)