Renal clearance parameters for PBPK model analysis of early lifestage differences in the disposition of environmental toxicants.

@article{Dewoskin2008RenalCP,
  title={Renal clearance parameters for PBPK model analysis of early lifestage differences in the disposition of environmental toxicants.},
  author={Robert S Dewoskin and Chad M Thompson},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2008},
  volume={51 1},
  pages={66-86}
}
Physiologically-based pharmacokinetic (PBPK) models are being developed to evaluate whether humans in early life are more or less susceptible to adverse effects than adults from exposure to chemicals because of reduced renal clearance. To support the development of such models, data on the rates of glomerular filtration, tubular secretion, tubular reabsorption, and renal blood flow in neonates and infants were compiled and summarized. All three processes are deficient in the newborn with… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 90 references

Human variability in the renal elimination of foreign compounds and renal excretion-related uncertainty factors for risk assessment.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2004
View 10 Excerpts
Highly Influenced

Renal Extraction of Para-aminohippurate in Infants and Children.

The Journal of clinical investigation • 1963
View 8 Excerpts
Highly Influenced

Maturation of Renal Function in Childhood: Clearance Studies.

The Journal of clinical investigation • 1949
View 5 Excerpts
Highly Influenced

The Ciba Collection of Medical Illustrations, Volume 3, Digestive System, Part I, Upper Digestive Tract

The Yale Journal of Biology and Medicine • 1960
View 6 Excerpts
Highly Influenced

Influence of postnatal age on kidney function of premature infants.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine • 1948
View 5 Excerpts
Highly Influenced

Measurement of Glomerular Filtration Rate in Premature Infants.

The Journal of clinical investigation • 1948
View 5 Excerpts
Highly Influenced

The Excretion of Inulin, Xylose and Urea by Normal and Phlorizinized Man.

The Journal of clinical investigation
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…