Renal clearance of glutathione measured in rats pretreated with inhibitors of glutathione metabolism.

@article{Scott1987RenalCO,
  title={Renal clearance of glutathione measured in rats pretreated with inhibitors of glutathione metabolism.},
  author={R D Scott and Norman P. Curthoys},
  journal={The American journal of physiology},
  year={1987},
  volume={252 5 Pt 2},
  pages={F877-82}
}
Renal clearance measurements were performed in rats pretreated with various inhibitors of glutathione metabolism. Approximately 97% of the renal gamma-glutamyltranspeptidase was inactivated by infusion of AT-125. Within 4.5 h arterial plasma concentration and urinary excretion of glutathione increased from 4 microM and 1.2 nmol/h to 27 microM and 3,900 nmol/h, respectively. The ratio of excreted to filtered glutathione increased from less than 0.01 to 1. When renal glutathione was decreased to… CONTINUE READING

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