Renal clearance in drug discovery and development: molecular descriptors, drug transporters and disease state.

@article{Feng2010RenalCI,
  title={Renal clearance in drug discovery and development: molecular descriptors, drug transporters and disease state.},
  author={Bo Feng and Jennnifer L LaPerle and George T. Chang and Manthena V S Varma},
  journal={Expert opinion on drug metabolism & toxicology},
  year={2010},
  volume={6 8},
  pages={939-52}
}
IMPORTANCE OF THE FIELD Kidney plays a key role in the elimination of xenobiotics and metabolic products from the body, where renal clearance is determined by glomerular filtration, tubular secretion and reabsorption processes. The proximal tubule of the nephron is equipped with multi-specificity uptake and efflux transporters for the secretion of a broad range of xenobiotics, while the compound physicochemical space drives the tubular reabsorption. Due to involvement of transporters, renal… CONTINUE READING
20 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…