Renal cell carcinomas in trichloroethene(TRI) exposed persons are associated with somatic mutations in the von Hippel-Lindau (VHL) tumour suppressor gene

@article{Brning1997RenalCC,
  title={Renal cell carcinomas in trichloroethene(TRI) exposed persons are associated with somatic mutations in the von Hippel-Lindau (VHL) tumour suppressor gene},
  author={Thomas Br{\"u}ning and Gregor Weirich and M. A. Hornauer and Heinz Hoefler and Hiltrud Brauch},
  journal={Archives of Toxicology},
  year={1997},
  volume={71},
  pages={332-335}
}
Renal cell carcinomas (RCC) develop as a consequence of somatic mutations of the von Hippel-Lindau (VHL) tumour suppressor gene. Recent epidemiological studies show that high and prolonged occupational exposures to trichloroethene (TRI) are associated with an increased incidence of RCC. Tumour tissues from 23 RCC patients with occupational histories of very high TRI exposure were analysed for somatic mutations within the VHL gene. DNA was isolated from microdissected tumour cells, amplified by… CONTINUE READING

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