Renal cathepsin G and angiotensin II generation.

  title={Renal cathepsin G and angiotensin II generation.},
  author={Jana Rykl and Joachim Thiemann and Sandra Kurzawski and T. Pohl and Johan Gobom and Walter Zidek and Hartmut Schl{\"u}ter},
  journal={Journal of hypertension},
  volume={24 9},
BACKGROUND Alternative pathways of angiotensin II biosynthesis play a significant role in the renin-angiotensin system. In this study porcine renal tissue was investigated for angiotensin II-generating enzymes. METHODS AND RESULTS Protein extracts from porcine renal tissue were fractionated by liquid chromatography and tested for their angiotensin II-generating activity by the mass-spectrometry-assisted enzyme screening system (MES) and the active fractions were purified to near homogeneity… CONTINUE READING
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