Renal carcinogenesis in models of diabetes in rats—metabolic changes are closely related to neoplastic development

@article{Dombrowski2007RenalCI,
  title={Renal carcinogenesis in models of diabetes in rats—metabolic changes are closely related to neoplastic development},
  author={Frank Dombrowski and L. Klotz and Peter Bannasch and Matthias Evert},
  journal={Diabetologia},
  year={2007},
  volume={50},
  pages={2580-2590}
}
There is an increased risk of renal cell carcinoma (RCC) in human diabetes mellitus. We therefore examined the influence of hyperglycaemia and glucose-lowering treatment on nephrocarcinogenesis in rats. Rats (n = 850), which were either spontaneously diabetic, streptozotocin-diabetic or normoglycaemic, were examined with special reference to Armanni–Ebstein lesions (AEL). Irrespective of the cause of diabetes, diabetic but not normoglycaemic rats developed typical glycogenotic clear-cell AEL… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Sequential phenotypic conversion of renal epithelial cells during neoplastic development

P Bannasch, E Nogueira, H Zerban, K Beck, D Mayer
1988
View 4 Excerpts
Highly Influenced

Diabetic tubular glycogenosis (Armanni-Ebstein-Lesion) is a preneoplastia of renal cell carcinomas in spontaneously-diabetic BB-rats

F Dombrowski, M Evert
Pathol Res Pract 202:292, • 2006
View 1 Excerpt

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