Renal arteriolar C4d deposition: a novel characteristic of hematopoietic stem cell transplantation-associated thrombotic microangiopathy.

@article{Laskin2013RenalAC,
  title={Renal arteriolar C4d deposition: a novel characteristic of hematopoietic stem cell transplantation-associated thrombotic microangiopathy.},
  author={Benjamin Lewis Laskin and Julia R. Maisel and Jens Goebel and Hong Yin and Guangju G. Luo and Jane C Khoury and Stella M. Davies and Sonata Jodele},
  journal={Transplantation},
  year={2013},
  volume={96 2},
  pages={217-23}
}
BACKGROUND The mechanism of kidney injury in hematopoietic stem cell transplantation (HSCT)-associated thrombotic microangiopathy (TA-TMA) is not completely understood. Renal C4d staining is a marker of classic complement activation and endothelial injury and has been described in preliminary reports of HSCT recipients with TA-TMA. Our objective was to evaluate complement in the pathogenesis of small vessel injury in children receiving HSCT. We hypothesized that kidney tissue from children with… CONTINUE READING

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C4d staining was performed by immunohistochemistry and evaluated on arterioles , peritubular capillaries , glomeruli , and tubular basement membranes .
C4d staining was performed by immunohistochemistry and evaluated on arterioles , peritubular capillaries , glomeruli , and tubular basement membranes .
Complement System ProteinsIs biochemical function of gene productcomplement C4d
Arteriolar C4d deposition may be a pathologic marker of TA - TMA , implicating localized complement fixation in HSCT recipients with kidney disease secondary to small vessel injury .
Arteriolar C4d deposition may be a pathologic marker of TA - TMA , implicating localized complement fixation in HSCT recipients with kidney disease secondary to small vessel injury .
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