Renal angiotensin receptor mapping in obese spontaneously hypertensive rats.

  title={Renal angiotensin receptor mapping in obese spontaneously hypertensive rats.},
  author={Paul R Ernsberger and Richard J. Koletsky and Laura A. Collins and Janice G. Douglas},
  volume={21 6 Pt 2},
Obese spontaneously hypertensive rats (SHR) develop nephropathy with severe proteinuria, but lean littermates do not develop renal disease. Intrarenal angiotensin has been suggested to contribute to nephropathy in other experimental models. We examined the regulation of angiotensin receptors as a reflection of target tissue response to possible changes in the renin-angiotensin system. We visualized angiotensin receptors in kidneys of 6-8-month-old obese SHR and their lean littermates. Both… CONTINUE READING
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