Renal and vascular actions of urotensin II.

  title={Renal and vascular actions of urotensin II.},
  author={Nick Ashton},
  journal={Kidney international},
  volume={70 4},
The peptide hormone urotensin II (UII) has been highly conserved through the vertebrates from fish to humans. As it was shown to be the endogenous ligand for the mammalian orphan G-protein-coupled receptor GPR14, now renamed the UT receptor, interest in UII physiology has grown. Initial observations of a potent vasoconstrictor effect have been tempered with the subsequent revelation of an endothelium-dependent vasodilator action. These complex and contrasting vascular actions are both species… CONTINUE READING