Renal and systemic hemodynamic effects of synthetic atrial natriuretic peptide in the anesthetized rat.

  title={Renal and systemic hemodynamic effects of synthetic atrial natriuretic peptide in the anesthetized rat.},
  author={Benn Dunn and Iekuni Ichikawa and Janice M. Pfeffer and Julia L. Troy and Barry M. Brenner},
  journal={Circulation research},
  volume={59 3},
To characterize the hemodynamic events responsible for alterations in renal function during administration of atrial natriuretic peptide, we studied the systemic, renal, and glomerular circulatory effects of intravenous rANP[126-149], administered as a 4 micrograms/kg prime and 0.5 microgram/kg per minute continuous infusion in anesthetized, euvolemic rats. With this protocol, a small decline in mean systemic arterial blood pressure occurred in the context of markedly enhanced urinary sodium… CONTINUE READING
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