Renal and cardiovascular response to nonhypotensive sepsis in a large animal model with peritonitis.

@article{Richmond1985RenalAC,
  title={Renal and cardiovascular response to nonhypotensive sepsis in a large animal model with peritonitis.},
  author={Joni M Richmond and J Findlay Walker and Alejandra Avila and A Petrakis and Richard J. Finley and William J Bill Sibbald and A. Leon Linton},
  journal={Surgery},
  year={1985},
  volume={97 2},
  pages={205-14}
}
We studied the functional effects of intraperitoneal sepsis on systemic hemodynamics in general, and on renal function in particular, in sheep in whom bacterial peritonitis was induced by cecal perforation. In the first group of seven sheep (group 1) fluid was administered throughout the period of sepsis to maintain pulmonary capillary wedge pressure as close to presepsis values as possible. These sheep exhibited hemodynamic changes known to be associated with sepsis in man: increased cardiac… CONTINUE READING