Renal amyloidosis caused by a novel stop-codon mutation in the apolipoprotein A-II gene.

@article{Yazaki2001RenalAC,
  title={Renal amyloidosis caused by a novel stop-codon mutation in the apolipoprotein A-II gene.},
  author={Masahide Yazaki and Juris J. Liepnieks and Toshiki Yamashita and Barbara G{\"u}nther and Martha Skinner and Merrill D L Benson},
  journal={Kidney international},
  year={2001},
  volume={60 5},
  pages={1658-65}
}
BACKGROUND Although apolipoprotein A-II (apoA-II) associated amyloidosis has been described in the senescent accelerated mouse (SAM) model of aging, so far there has been no report of human apoA-II amyloidosis except for a recent report of renal amyloidosis resulting from a stop-codon to glycine mutation of apoA-II. The mechanisms of amyloid formation in human apoA-II amyloidosis are not clear. METHODS A 46-year-old Caucasian male with proteinuria noted at 42 years of age was studied. Renal… CONTINUE READING
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