Renal allografts with IF/TA display distinct expression profiles of metzincins and related genes.

@article{Roedder2009RenalAW,
  title={Renal allografts with IF/TA display distinct expression profiles of metzincins and related genes.},
  author={Silke Roedder and A Scherer and Friedrich Raulf and Celine C. Berthier and Alexandre Hertig and Lionel Couzi and Antoine Durrbach and {\'E}ric Rondeau and H-P Marti},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2009},
  volume={9 3},
  pages={
          517-26
        }
}
Chronic renal allograft injury is often reflected by interstitial fibrosis (IF) and tubular atrophy (TA) without evidence of specific etiology. In most instances, IF/TA remains an irreversible disorder, representing a major cause of long-term allograft loss. As members of the protease family metzincins and functionally related genes are involved in fibrotic and sclerotic processes of the extracellular matrix (ECM), we hypothesized their deregulation in IF/TA. Gene expression and protein level… CONTINUE READING

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