Renal adverse effects of nonsteroidal anti-inflammatory drugs.

  title={Renal adverse effects of nonsteroidal anti-inflammatory drugs.},
  author={Sam Harirforoosh and Fakhreddin Jamali},
  journal={Expert opinion on drug safety},
  volume={8 6},
NSAIDs depress prostaglandins synthesis through inhibition of COX-1 that is involved in maintaining cell integrity and COX-2 that, although presents particularly in the kidneys, is overexpressed in response to inflammation. Both the beneficial and side effects of NSAIDs are, therefore, through their inhibition of COX enzymes. Introduction of COX-2-selective inhibitors has improved the safety profile of the drugs with regard to their most common side effect which occurs at the gastrointestinal… CONTINUE READING


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