Renal accumulation and urinary excretion of cisplatin in diabetic rats.

@article{Valentovic1991RenalAA,
  title={Renal accumulation and urinary excretion of cisplatin in diabetic rats.},
  author={Monica A Valentovic and Laura A. Scott and E. Madan and Robert A. Yokel},
  journal={Toxicology},
  year={1991},
  volume={70 2},
  pages={151-62}
}
Previous work has demonstrated that cisplatin nephrotoxicity was attenuated in streptozotocin (STZ)-induced diabetic rats. The following studies investigated the hypothesis that renal cisplatin accumulation was reduced in diabetic rats. Male Fischer 344 (F344) rats were injected with 32 mg/kg STZ (i.p.) or citrate buffer. Renal platinum (Pt) accumulation was quantitated 0-96 h after the administration of 5 mg/kg cisplatin (i.p.) to normoglycemic and diabetic rats (greater than or equal to 4… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…