Renal TLR4 mRNA expression correlates with inflammatory marker MCP-1 and profibrotic molecule TGF-β₁ in patients with chronic kidney disease.

@article{Lepenies2011RenalTM,
  title={Renal TLR4 mRNA expression correlates with inflammatory marker MCP-1 and profibrotic molecule TGF-β₁ in patients with chronic kidney disease.},
  author={Julia Lepenies and Kevin Sean Eardley and Tina Kienitz and Martin Hewison and Thomas Ihl and P. M. Stewart and Paul Cockwell and Marcus Quinkler},
  journal={Nephron. Clinical practice},
  year={2011},
  volume={119 2},
  pages={c97-c104}
}
BACKGROUND Toll-like receptor-4 (TLR4) has been implicated in the pathogenesis of different renal diseases in rodent models. However, in human kidney disease, TLR4 expression and regulation is not well understood. We hypothesized that renal TLR4 expression plays a role in chronic kidney disease (CKD) and is associated with proteinuria, kidney function, histological diagnosis, and inflammatory mediators. METHODS We quantified TLR4 mRNA as well as expression of macrophage chemoattractant… CONTINUE READING

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