Renal Subcapsular xenografing of human fetal external genital tissue - A new model for investigating urethral development.

@article{Isaacson2017RenalSX,
  title={Renal Subcapsular xenografing of human fetal external genital tissue - A new model for investigating urethral development.},
  author={Dylan Isaacson and Joel Shen and Mei Zhen Cao and Adriane Watkins Sinclair and Xuan Yue and Gerald R. Cunha and Laurence S. Baskin},
  journal={Differentiation; research in biological diversity},
  year={2017},
  volume={98},
  pages={
          1-13
        }
}
In this paper, we introduce our novel renal subcapsular xenograft model for the study of human penile urethral and clitoral development. We grafted fifteen intact fetal penes and clitorides 8-11 weeks fetal age under the renal capsules of gonadectomized athymic mice. The mice were treated with a subcutaneous pellet of dihydrotestosterone (DHT), diethylstilbestrol (DES) or untreated with hormones. Xenografts were harvested after fourteen days of growth and analyzed via serial histologic… CONTINUE READING