Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-κB Pathway in Diabetic Rats

@inproceedings{Wu2013RenalPR,
  title={Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-κB Pathway in Diabetic Rats},
  author={Jia-sheng Wu and Rong Shi and Jie Zhong and Xiong Nian Lu and Bing-liang Ma and Tian-ming Wang and Bin Zan and Yue-Ming Ma and Neng-neng Cheng and Fu-rong Qiu},
  booktitle={Evidence-based complementary and alternative medicine : eCAM},
  year={2013}
}
In Chinese medicine, Xiexin decoction (XXD) has been used for the clinical treatment of diabetes for at least 1700 years. The present study was conducted to investigate the effective ingredients of XXD and their molecular mechanisms of antidiabetic nephropathy in rats. Rats with diabetes induced by high-fat diet and streptozotocin were treated with XXD extract for 12 weeks. XXD significantly improved the glucolipid metabolism disorder, attenuated albuminuria and renal pathological changes… CONTINUE READING
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