Renal Na/H exchanger NHE-3 and Na-PO4 cotransporter NaPi-2 protein expression in glucocorticoid excess and deficient states.

@article{Loffing1998RenalNE,
  title={Renal Na/H exchanger NHE-3 and Na-PO4 cotransporter NaPi-2 protein expression in glucocorticoid excess and deficient states.},
  author={Johannes Loffing and Marius R Loetscher and Brigitte Kaissling and Jurg Biber and Heini Murer and Mouin G. Seikaly and Robert J. Alpern and Moshe Levi and Michel Baum and Orson W Moe},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1998},
  volume={9 9},
  pages={1560-7}
}
Administration of pharmacologic doses of glucocorticoid in vivo increases renal proximal tubule apical membrane Na/H exchange and decreases Na/PO4 cotransport activity (1). Current data suggest that the NHE-3 and NaPi-2 proteins mediate significant fractions of proximal tubule apical membrane Na/H exchange and Na/PO4 cotransport, respectively. This study examines whether glucocorticoid excess or deficiency affects NHE-3 and NaPi-2 protein abundance and the intrarenal distribution of these… CONTINUE READING

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