Renal Effects of COX-2-Selective Inhibitors

  title={Renal Effects of COX-2-Selective Inhibitors},
  author={Dr D. Craig Brater and Cynthia J Harris and Jan Stephen Redfern and Barry J. Gertz},
  journal={American Journal of Nephrology},
  pages={1 - 15}
Although nonsteroidal anti-inflammatory drugs (NSAIDs) effectively treat a variety of inflammatory diseases, these agents may cause deleterious effects on kidney function, especially with respect to solute homeostasis and maintenance of renal perfusion and glomerular filtration. NSAIDs act by reducing prostaglandin biosynthesis through inhibition of cyclooxygenase (COX) which exists as two isoforms (COX-1 and COX-2). NSAID-induced gastrointestinal toxicity is generally believed to occur through… 

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