Renal Effects of COX-2-Selective Inhibitors

@article{Brater2001RenalEO,
  title={Renal Effects of COX-2-Selective Inhibitors},
  author={Dr D. Craig Brater and Cynthia J Harris and Jan Stephen Redfern and Barry J. Gertz},
  journal={American Journal of Nephrology},
  year={2001},
  volume={21},
  pages={1 - 15}
}
Although nonsteroidal anti-inflammatory drugs (NSAIDs) effectively treat a variety of inflammatory diseases, these agents may cause deleterious effects on kidney function, especially with respect to solute homeostasis and maintenance of renal perfusion and glomerular filtration. NSAIDs act by reducing prostaglandin biosynthesis through inhibition of cyclooxygenase (COX) which exists as two isoforms (COX-1 and COX-2). NSAID-induced gastrointestinal toxicity is generally believed to occur through… Expand

Paper Mentions

Anti-inflammatory agents and renal function.
  • D. Brater
  • Medicine
  • Seminars in arthritis and rheumatism
  • 2002
TLDR
Patients who are at risk for adverse renal events should be monitored with the same caution when receiving coxibs as when receiving treatment with nonselective NSAIDs. Expand
COX-2 and the Kidney
TLDR
Caution should be taken when COX-2 inhibitors are prescribed, especially in high-risk patients (including elderly patients and patients with volume depletion). Expand
RENAL TOXICITY OF THE SELECTIVE CYCLOOXYGENASE-2 INHIBITORS: CELECOXIB AND ROFECOXIB
TLDR
The conclusion was that the selective cyclooxygenase-2 inhibitors don’t have higher renal safety than other non-steroidal anti-inflammatory drugs and, like them, must be used either cautiously or not at all in patients with predisposing diseases. Expand
COX-2 selective inhibitors: analysis of the renal effects
TLDR
COX-2 selective inhibitors provide analgesia and blunt inflammation while also sparing the gastrointestinal tract from classic NSAID toxicity while also suggesting a role for this isoform in maintenance of physiological renal processes. Expand
Non-steroidal antiinflammatory drugs (NSAIDs) (ยาลดการอักเสบที่ไม่ใช่เสตียรอยด์)
TLDR
All COX-2 inhibitors have comparable efficacy to traditional NSAIDs but provide a slightly better gastrointestinal safety profile and carry some potential cardiovascular risks, particularly when taking at high doses for prolonged periods of time. Expand
Nonsteroidal Anti-Inflammatory Drugs and the Kidney
TLDR
This review summarizes the present knowledge how traditional NSAIDs and selective COX-2 inhibitors may affect the kidney under various experimental and clinical conditions, and how these drugs may influence renal inflammation, water transport, sodium and potassium balance and how renal dysfunction or hypertension may result. Expand
Immunohistochemical localisation of renal cyclooxygenase-1 expression in non-steroidal anti-inflammatory drug-treated mice.
  • M. Meskell, R. Ettarh
  • Biology, Medicine
  • Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2011
TLDR
Reports of reduced COX-1 expression prior to renal tissue damage following high-dose indomethacin treatment suggest that effects of NSAIDs on renal COX expression are dependent on dose and may be related to isoform specificity. Expand
Novel mechanisms of nonsteroidal anti-inflammatory drug-induced renal toxicity
TLDR
The common involvement of UGT in the metabolism of arachidonic acid, eicosanoids and NSAIDs is discussed in the context of novel mechanisms of NSAID-induced nephrotoxicity. Expand
Potential Cardiovascular Effects of COX-2 Selective Nonsteroidal Antiinflammatory Drugs
  • R. Fowles
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  • Journal of pain & palliative care pharmacotherapy
  • 2003
The newly developed nonsteroidal antiinflammatory drugs (NSAIDs) that selectively inhibit cyclooxygenase-2 (COX-2), are effective against pain and inflammation and appear to have lessExpand
The Renal Effects of Traditional Nonsteroidal Anti-Inflammatory Agents Versus Cyclooxygenase-2 Inhibitors
TLDR
Because many older patients have conditions that place them in one of the “at-risk” categories, this population should be monitored closely for the development of renal adverse events from any NSAIDs, including COX-2-selective agents. Expand
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