Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System.

@article{Trepiccione2016RenalAR,
  title={Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System.},
  author={Francesco Trepiccione and Simon D. Gerber and Florian Grahammer and Karen I L{\'o}pez-Cayuqueo and V{\'e}ronique Baudrie and Teodor G. Păunescu and Diane E. Capen and Nicolas Picard and R Todd Alexander and Tobias B Huber and R{\'e}gine Chambrey and Dennis L. Brown and Pascal Houillier and Dominique Eladari and Matias Simons},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2016},
  volume={27 11},
  pages={3320-3330}
}
ATPase H+-transporting lysosomal accessory protein 2 (Atp6ap2), also known as the (pro)renin receptor, is a type 1 transmembrane protein and an accessory subunit of the vacuolar H+-ATPase (V-ATPase) that may also function within the renin-angiotensin system. However, the contribution of Atp6ap2 to renin-angiotensin-dependent functions remains unconfirmed. Using mice with an inducible conditional deletion of Atp6ap2 in mouse renal epithelial cells, we found that decreased V-ATPase expression and… CONTINUE READING
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