Renal, cardiovascular and metabolic effects of fetal programming.

  title={Renal, cardiovascular and metabolic effects of fetal programming.},
  author={Nadezda Koleganova and Kerstin Benz and Grzegorz Piecha and Eberhard Ritz and Kerstin Amann},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={27 8},
Disturbed fetal development has long-lasting effects on the offspring, specifically a higher risk of renal, cardiovascular and metabolic disease in adult life as postulated by Barker’s hypothesis. Relevant to renal outcomes of the offspring are maternal factors such as pre-eclampsia, malnutrition, smoking, drugs etc. The main renal abnormalities in the offspring include reduced nephron number and higher risk of low glomerular filtration rate, albuminuria, hypertension and worse outcome of… CONTINUE READING
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