Renaissance of NMDA receptor antagonists: do they have a role in the pharmacotherapy for alcoholism?

@article{Nagy2004RenaissanceON,
  title={Renaissance of NMDA receptor antagonists: do they have a role in the pharmacotherapy for alcoholism?},
  author={J{\'o}zsef Nagy},
  journal={IDrugs : the investigational drugs journal},
  year={2004},
  volume={7 4},
  pages={339-50}
}
  • József Nagy
  • Published 2004 in IDrugs : the investigational drugs journal
Long-term alcohol exposure leads to the development of alcohol dependence, which is possibly induced by changes in specific neurotransmitter functions. Accumulating evidence suggests that the N-methyl-D-aspartate (NMDA) type of ionotropic glutamate receptor is a particularly important site of action for ethanol. Ethanol potently and selectively inhibits… CONTINUE READING