Remyelination is altered by bone morphogenic protein signaling in demyelinated lesions.

  title={Remyelination is altered by bone morphogenic protein signaling in demyelinated lesions.},
  author={Jennifer K. Sabo and Tim Douglas Aumann and Daniel Merlo and Trevor J. Kilpatrick and Holly S. Cate},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={31 12},
Remyelination of the CNS involves the regeneration of mature oligodendrocytes by endogenous oligodendrocyte progenitor cells (OPCs). Previous studies have shown that bone morphogenic proteins (BMPs) inhibit the production of oligodendrocytes in the healthy CNS. However, there is currently no information on the influence of BMP signaling in vivo within demyelinated lesions of the brain or on subsequent remyelination. Here, we determine a role for BMP signaling in modulating… CONTINUE READING
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