Remoxipride shows low propensity to block functional striatal dopamine D2 receptors in vitro.

@article{WestlindDanielsson1994RemoxiprideSL,
  title={Remoxipride shows low propensity to block functional striatal dopamine D2 receptors in vitro.},
  author={A. Westlind-Danielsson and K. Gustafsson and I. Andersson},
  journal={European journal of pharmacology},
  year={1994},
  volume={288 1},
  pages={
          89-95
        }
}
The effect of remoxipride ((S)(-)3-bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,6-dimethoxybenzam ide) on dopamine D2 receptor-mediated inhibition of cAMP formation in rat striatal tissues pieces was established together with that of a number of other dopamine D2 receptor antagonists. The action of remoxipride, three other substituted benzamides, (-)-sulpiride, raclopride and NCQ 298 ((S)-3-iodo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5,6-dimethoxysalicylam ide mesylate) and haloperidol, a… Expand
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References

SHOWING 1-10 OF 25 REFERENCES
Binding characteristics of remoxipride and its metabolites to dopamine D2 and D3 receptors.
TLDR
The present in vitro results suggest that the behavioural effects of remoxipride in rats may reflect the effect of remxipride and some of its high-affinity metabolites. Expand
Autoradiographic distribution of the D1 agonist [3H]SKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors
TLDR
The regional distribution of the specific D1 agonist [3H]SKF 38393 has been studied autoradiographically in the rat CNS confirming the view that nigral D1 but not D2 receptors are located on striatonigral fibres. Expand
Disposition of remoxipride in different species. Species differences in metabolism.
TLDR
The pharmacokinetics and metabolism of the new antipsychotic agent remoxipride was studied in rodents, dogs and human subjects using the unlabelled or the labelled (3H or 14C) drug. Expand
D2dopamine receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in rat striatum
TLDR
The results suggest that forskolin may be used as a tool for amplifying the abolute D2-receptor-mediated inhibition of adenylate cyclase in rat striatal homogenates. Expand
Quantitative autoradiographic localization of the D1 and D2 subtypes of dopamine receptors in rat brain
The distribution of D1 and D2 receptors was studied in coronal sections of rat brain, using quantitative autoradiography. D1 receptors were labeled with 1.8 nM 3H-SKF-83566 (a brominated analog ofExpand
Forskolin Potentiates the Stimulation of Rat Striatal Adenylate Cyclase Mediated by D‐1 Dopamine Receptors, Guanine Nucleotides, and Sodium Fluoride
Abstract: We report here that forskolin acts in a synergistic manner with dopaminergic agonists, guanine nucleotides, or sodium fluoride to potentiate the stimulation of rat striatal adenylateExpand
D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons.
TLDR
The differential effects of dopamine on striatonigral and striatopallidal neurons are mediated by their specific expression of D1 and D2 dopamine receptor subtypes, respectively. Expand
Specific Inhibition of Dopamine D‐1‐Mediated Cyclic AMP Formation by Dopamine D‐2, Muscarinic Cholinergic, and Opiate Receptor Stimulation in Rat Striatal Slices
TLDR
These inhibitory agents were unable to reduce the ability of a number of other agonists, including isoprenaline, prostaglandin E1, 2‐chloroadenosine, vasoactive intestinal polypeptide, and cholera toxin, to increase cyclic AMP levels in striatal slices. Expand
Dopamine receptors: molecular biology, biochemistry and behavioural aspects.
TLDR
Progress has been made in understanding the function of DA-containing discrete brain nuclei and the functional consequence of the DA's interaction with other neurotransmitters, and some of the latest advances in these various areas are explored. Expand
D1 and D2 dopamine receptor mRNA in rat brain.
  • D. Weiner, A. Levey, +4 authors M. Brann
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1991
TLDR
Insight is provided into the neuroanatomical basis of the differential effects of drugs that act on D1 or D2 receptors by mapping the cellular expression of the corresponding mRNAs in rat brain by in situ hybridization histochemistry. Expand
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