Removing pathogenic memories

@article{Centonze2007RemovingPM,
  title={Removing pathogenic memories},
  author={Diego Centonze and Alberto Siracusano and Paolo Calabresi and Giorgio Bernardi},
  journal={Molecular Neurobiology},
  year={2007},
  volume={32},
  pages={123-132}
}
Experimental research examining the neural bases of nondeclarative memory has offered intriguing insight into how functional and dysfunctional implicit learning affects the brain. Long-term modifications of synaptic transmission, in particular, are currently considered the most plausible mechanism underlying memory trace encoding and compulsions, addiction, anxiety, and phobias. Therefore, an effective psychotherapy must be directed to erase maladaptive implicit memories and aberrant synaptic… 
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References

SHOWING 1-10 OF 98 REFERENCES
Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective
Molecular bases of long-term memories: a question of persistence
  • Y. Dudai
  • Biology
    Current Opinion in Neurobiology
  • 2002
Synaptic plasticity and memory: an evaluation of the hypothesis.
TLDR
It is concluded that a wealth of data support the notion that synaptic plasticity is necessary for learning and memory, but that little data currently supports the notion of sufficiency.
The endogenous cannabinoid system controls extinction of aversive memories
TLDR
Treatment of wild-type mice with the CB1 antagonist SR141716A mimicked the phenotype of CB1-deficient mice, revealing that CB1 is required at the moment of memory extinction, and proposes that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala.
Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala
TLDR
The results show that infusion of the NMDA antagonist D,L-2- amino-5-phosphonovaleric acid (AP5) into the amygdala, a limbic structure known to be important for fear conditioning, dose-dependently blocked extinction of conditioned fear and suggest that an NMDA-dependent process might underlie the extinction of Conditioned fear.
Suppressing unwanted memories by executive control
TLDR
It is shown that executive control processes not uniquely tied to trauma may provide a viable model for repression, and that this cognitive act has enduring consequences for the rejected memories.
Reconsolidation of memory after its reactivation
The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses
TLDR
This book aims to investigate elementary forms of learning and memory at a cellular molecular level—as specific molecular activities within identified nerve cells withinidentified nerve cells.
Progress in Understanding the Factors Regulating Reversibility of Long-term Potentiation
TLDR
The recent data concerning putative depotentiation mechanisms and the implications of this phenomenon in the mechanisms of "forgetting" are summarized, and the prevention of saturation of the storage capacity of a neuronal network is discussed.
...
...