Removals of hydrogen peroxide and hydroxyl radical by thiol-specific antioxidant protein as a possible role in vivo.

@article{Lim1993RemovalsOH,
  title={Removals of hydrogen peroxide and hydroxyl radical by thiol-specific antioxidant protein as a possible role in vivo.},
  author={Yin Sze Lim and M K Cha and Hyung Ki Kim and Taewoong Uhm and Junguk Park and Kyunggon Kim and Ihn Kim},
  journal={Biochemical and biophysical research communications},
  year={1993},
  volume={192 1},
  pages={
          273-80
        }
}
Thiol-specific antioxidant protein (Protector Protein; PRP) from Saccharomyces cerevisiae was found to remove hydrogen peroxide and hydroxyl radical in the presence of dithiothreitol (DTT). Without DTT as a reducing equivalent, the antioxidant protein did not show the activities for destroying hydrogen peroxide and hydroxyl radical. N-ethylmaleimide (NEM) was observed to prevent the PRP from both removing hydrogen peroxide and protecting the cleavage of DNA. These observations suggest that the… CONTINUE READING
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