Removal or maintenance of inositol-linked acyl chain in glycosylphosphatidylinositol is critical in trypanosome life cycle.

@article{Hong2006RemovalOM,
  title={Removal or maintenance of inositol-linked acyl chain in glycosylphosphatidylinositol is critical in trypanosome life cycle.},
  author={Yeonchul Hong and Kisaburo Nagamune and Yasu S. Morita and Fumiki Nakatani and Hisashi Ashida and Yusuke Maeda and Taroh Kinoshita},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 17},
  pages={11595-602}
}
The protozoan parasite Trypanosoma brucei is coated by glycosylphosphatidylinositol (GPI)-anchored proteins. During GPI biosynthesis, inositol in phosphatidylinositol becomes acylated. Inositol is deacylated prior to attachment to variant surface glycoproteins in the bloodstream form, whereas it remains acylated in procyclins in the procyclic form. We have cloned a T. brucei GPI inositol deacylase (GPIdeAc2). In accordance with the acylation/deacylation profile, the level of GPIdeAc2 mRNA was 6… CONTINUE READING