Removal of xenoreactive human anti-pig antibodies by absorption on recombinant mucin-containing glycoproteins carrying the Gal alpha1,3Gal epitope.

@article{Liu1997RemovalOX,
  title={Removal of xenoreactive human anti-pig antibodies by absorption on recombinant mucin-containing glycoproteins carrying the Gal alpha1,3Gal epitope.},
  author={Jining Liu and Yueming Qian and Jan Holgersson},
  journal={Transplantation},
  year={1997},
  volume={63 11},
  pages={1673-82}
}
BACKGROUND The hyperacute rejection caused by preformed natural antibodies in the recipient species reacting with donor species endothelial antigens is one of the major obstacles preventing routine use of clinical xenotransplantation. Based on the known structure and biosynthetic pathway of the major porcine xenoantigen, Gal alpha1,3Gal, we developed a novel strategy aimed at specific removal of human, natural anti-pig antibodies. METHODS Cotransfection of COS cells with expression plasmids… CONTINUE READING
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