Removal of vanadium by combining desferrioxamine and deferiprone chelators in rats

@article{Tubafard2009RemovalOV,
  title={Removal of vanadium by combining desferrioxamine and deferiprone chelators in rats},
  author={Solmaz Tubafard and Seyed Jamilaldine Fatemi and Amir Shokooh Saljooghi and Masoud Torkzadeh},
  journal={Medicinal Chemistry Research},
  year={2009},
  volume={19},
  pages={854-863}
}
Investigations were conducted to evaluate the ability of two chelators, desferrioxamine (DFO), and deferiprone (1,2-dimethy1-3-hydroxypyride-4-one, L1), for the excretion of vanadium after a period of administration of vanadium salts in 6-week-old male Wistar rats. Immediately after 60 days of vanadium administration, the rats received chelators (L1, DFO or L1 + DFO) for a period of 1 week. Chelators were given orally (L1), intraperitoneally (DFO), or both to different groups of rats at two… CONTINUE READING

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