Removal of proteasomes from the nucleus and their accumulation in apoptotic blebs during programmed cell death

@article{Pitzer1996RemovalOP,
  title={Removal of proteasomes from the nucleus and their accumulation in apoptotic blebs during programmed cell death},
  author={Frank Pitzer and Ada Dantes and Thomas Fuchs and Wolfgang Baumeister and Abraham Amsterdam},
  journal={FEBS Letters},
  year={1996},
  volume={394}
}

Intracellular localization of proteasomes.

The role of the ubiquitin-proteasome pathway in apoptosis

TLDR
This review provides a summary of the experimental basis by which components of the ubiquitin-proteasome pathway have been linked to apoptosis, and attempts are made to formulate a hypothesis about its role in this process.

Autophagy Regulates the Post-Translational Cleavage of BCL-2 and Promotes Neuronal Survival

TLDR
The cellular content of BCL-2 is regulated at post-translational level along the autophagy/lysosome pathways in organotypic cultures of post-natal mouse cerebellar cortex in order to understand the pivotal role of calcium release from intracellular stores in CGC neuroprotection.

Proteasome Involvement and Accumulation of Ubiquitinated Proteins in Cerebellar Granule Neurons Undergoing Apoptosis

TLDR
The finding that the proteasomes are early involved in apoptosis and that ubiquitinated proteins accumulate during this process prospect granule neurons as a model system aimed at correlating these events with neurodegenerative diseases is found.

Rho GTPase signalling pathways in the morphological changes associated with apoptosis

TLDR
This review will discuss how Rho GTPase signalling pathways affect the structure of the actin cytoskeleton and allow for the efficient clearance of apoptotic cells.

Actin depolymerization and polymerization are required during apoptosis in endothelial cells

TLDR
It is suggested that the actin network of flattened cells is disrupted concomitantly to the morphological modifications associated to the apoptotic cell death, and that the cytochalasin‐sensitive reorganisation of actin is required to the formation of apoptotic blebs.

Apoptotic Membrane Blebbing Is Regulated by Myosin Light Chain Phosphorylation

TLDR
The model system described here should facilitate future studies of MLCK, Rho, and other signal transduction pathways activated during the execution phase of apoptosis and also implicate Rho signaling in these active morphological changes.

cAMP-INDUCED APOPTOSIS IN GRANULOSA CELLS IS ASSOCIATED WITH UP-REGULATION OF P53 AND BAX AND DOWN-REGULATION OF CLUSTERIN

TLDR
The data of the present study suggest that cAMP may activate apoptosis in granulosa cells by shifting the ratio of the death promoter to death repressor genes via alteration of P53 and bax expression.
...

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