Removal of endothelium-dependent relaxation by antibody and complement in afferent arterioles.

@article{Juncos1994RemovalOE,
  title={Removal of endothelium-dependent relaxation by antibody and complement in afferent arterioles.},
  author={Luis A Juncos and Sadayoshi Ito and Oscar A. Carretero and Jeffrey L. Garvin},
  journal={Hypertension},
  year={1994},
  volume={23 1 Suppl},
  pages={I54-9}
}
Studies of endothelial regulation of microvascular function have been hampered by the technical difficulty of removing the endothelium without damaging the vascular smooth muscle cells. This study presents a novel method of endothelial damage and lysis based on the facts that endothelial cells express specific antigens and that complement reacts with antibody/antigen complexes, causing cell lysis. We isolated and perfused rabbit glomerular afferent arterioles in vitro and examined vascular… CONTINUE READING