Removal of chloroform from biodegradable therapeutic microspheres by radiolysis.

@article{Zielhuis2006RemovalOC,
  title={Removal of chloroform from biodegradable therapeutic microspheres by radiolysis.},
  author={Sander W Zielhuis and Johannes Franciscus Wilhelmus Nijsen and Lambertus Dorland and Gerard Cornelis Krijger and Alfred D. van het Schip and Wim E Hennink},
  journal={International journal of pharmaceutics},
  year={2006},
  volume={315 1-2},
  pages={67-74}
}
Radioactive holmium-166 loaded poly(l-lactic acid) microspheres are promising systems for the treatment of liver malignancies. These microspheres are loaded with holmium acetylacetonate (HoAcAc) and prepared by a solvent evaporation method using chloroform. After preparation the microspheres (Ho-PLLA-MS) are activated by neutron irradiation in a nuclear… CONTINUE READING