Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells.

@article{Gassmann2010RemovalOS,
  title={Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells.},
  author={Reto Gassmann and Andrew J Holland and Dileep Varma and Xiaohu Wan and Filiz Civril and Don W Cleveland and Karen Oegema and Edward D. Salmon and Arshad Desai},
  journal={Genes & development},
  year={2010},
  volume={24 9},
  pages={957-71}
}
The spindle checkpoint generates a "wait anaphase" signal at unattached kinetochores to prevent premature anaphase onset. Kinetochore-localized dynein is thought to silence the checkpoint by transporting checkpoint proteins from microtubule-attached kinetochores to spindle poles. Throughout metazoans, dynein recruitment to kinetochores requires the protein Spindly. Here, we identify a conserved motif in Spindly that is essential for kinetochore targeting of dynein. Spindly motif mutants… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 69 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 70 references

Similar Papers

Loading similar papers…