Removal of P-cresol sulfate by hemodialysis.

@article{Martinez2005RemovalOP,
  title={Removal of P-cresol sulfate by hemodialysis.},
  author={Andres W. Martinez and Natalie S. Recht and Thomas H. Hostetter and Timothy W. Meyer},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2005},
  volume={16 11},
  pages={
          3430-6
        }
}
Protein-bound solutes are poorly cleared by dialysis. Among the most extensively studied of these solutes is p-cresol, which has been shown to be toxic in vitro. This study examined the form in which p-cresol circulates and quantified its removal by hemodialysis. HPLC analysis of plasma from hemodialysis patients contained a peak whose mobility corresponded to synthetic p-cresol sulfate (PCS) but no detectable unconjugated p-cresol. Treatment with sulfatase resulted in recovery of this peak as… CONTINUE READING

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