Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity

@inproceedings{Gordon2014RemovalO8,
  title={Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity},
  author={Alasdair J. E. Gordon and Dominik Satory and Mengyu Wang and Jennifer A. Halliday and Ido Golding and Christophe Herman},
  booktitle={Nucleic acids research},
  year={2014}
}
Living in an oxygen-rich environment is dangerous for a cell. Reactive oxygen species can damage DNA, RNA, protein and lipids. The MutT protein in Escherichia coli removes 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP) from the nucleotide pools precluding incorporation into DNA and RNA. While 8-oxo-dGTP incorporation into DNA is mutagenic, it is not clear if 8-oxo-GTP incorporation into RNA can have phenotypic consequences for the cell. We use a… CONTINUE READING

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